Simultaneous Prediction of Area Under the Curves of Mycophenolic Acid and Its Metabolites and Enterohepatic Recirculation in Kidney Transplant Recipients.

ABSTRACT:

Background

Therapeutic drug monitoring of mycophenolic acid (MPA) is limited due to the requirement for intensive pharmacokinetic sampling to assess the area under the curve (AUC). Limited sampling strategies (LSS) offer a practical alternative; however, enterohepatic recirculation (EHR) affects prediction accuracy and precision. This study is the first to develop LSS models capable of simultaneously predicting the AUC of MPA, its metabolites [mycophenolic acid glucuronide (MPAG) and acyl mycophenolic acid glucuronide (Acyl-MPAG)], and MPA EHR in kidney transplant recipients (KTRs).

Methods

Intensive pharmacokinetic sampling was conducted in 84 adult KTRs receiving mycophenolate mofetil. MPA AUC 0-12 was calculated, and MPA EHR was determined. During the development of the L

SUBMITTER: Mohamed ME 

PROVIDER: S-EPMC12871475 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature