Single-cell and machine learning integration reveals OS-driven CCND1 promotes an aggressive phenotype in papillary thyroid carcinoma.

ABSTRACT:

Background

Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, with rising incidence worldwide. Oxidative stress (OS), characterized by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, plays a critical role in tumor initiation and progression. However, the specific relationship between OS and PTC remains underexplored, highlighting the need for further investigation. This study aims to identify OS-related biomarkers in PTC that could potentially be used for clinical diagnosis and treatment.

Methods

Single-cell RNA sequencing data from PTC and normal thyroid tissues were analyzed using multiple gene set scoring and differential expression methods to evaluate OS levels across different cell types. Integrated bioinformatics analy

SUBMITTER: Wang J 

PROVIDER: S-EPMC12871538 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature