Impact of impaired endogenous neurosteroidogenesis on outcomes following chronic alcohol exposure.

ABSTRACT: Alcohol use disorder is a major public health concern worldwide and there is a high comorbidity with psychiatric disorders. The basolateral amygdala (BLA) has been implicated in both mood and alcohol use disorders; however, the mechanisms contributing to the shared pathophysiology remain unknown. Extensive evidence indicates that ethanol modulates GABAergic signaling in the BLA, including actions on neurosteroid-sensitive, extrasynaptic δ subunit-containing GABA_A receptors (GABA_ARs), which has been suggested to mediate many of the behavioral effects. In fact, several studies have suggested that 5α-reduced neurosteroids, such as allopregnanolone, may mediate some of the behavioral effects of alcohol. Here we demonstrate that chronic intermittent ethanol (CIE) exposure

SUBMITTER: Blandino K 

PROVIDER: S-EPMC12871643 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature