Starve-Feed Cycles Direct Quiescence to Proliferation Transitions in <i>Drosophila</i> Follicle Stem Cells via Transcriptional Regulation.

ABSTRACT: Stem cell quiescence is a reversible state in which cells temporarily exit the cell cycle but remain poised to re-enter, on cue. Robust protection of the balance between stem cell quiescence and proliferation (Q->P) is critical for long-term tissue health. Proliferation without proper resources drives disease states including cancer or birth defects. Conversely, extended periods of quiescence can lead to irreversible senescence, causing stem cell loss, aging symptoms, and vulnerability to oncogenic transformation. Diet is a central regulator of Q->P. Tissue stem cells are particularly impacted, entering periods of quiescence during nutrient restriction, with rapid induction of proliferation upon feeding. We demonstrated previously that the Hedgehog (Hh) signaling pathway is necessary and s

SUBMITTER: Lee EH 

PROVIDER: S-EPMC12871697 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature