Cortico-basal ganglia dynamics of global and selective response inhibition in humans.

ABSTRACT: Response inhibition is an important cognitive control mechanism, which enables flexible behavior by stopping inappropriate actions. Intracranial recordings across species have identified a neural circuit that implements response inhibition via the subthalamic nucleus of the basal ganglia. However, this work has been limited to simple tasks, in which unequivocal, salient "stop"-signals require the inhibition of all ongoing responses. Notably, response inhibition in the real world is substantially different. Real-world response inhibition is selective: it occurs only after specific salient signals ('stimulus-selectivity') and stops only specific movements, while others continue ('response-selectivity'). If and how the fronto-subthalamic system implements selective inhibition is largely unkno

SUBMITTER: Soh C 

PROVIDER: S-EPMC12871802 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature