Environmental Fungi Modulate the Vaginal Mycobiome and Cervical Disease Progression in Hispanic Women.

ABSTRACT: The vaginal mycobiome, though a minor component of the cervicovaginal ecosystem, plays a crucial role in reproductive health and disease. However, its composition and interactions with bacterial communities remain poorly understood, particularly among Hispanic women, who experience disproportionately high rates of Human papillomavirus (HPV) infection and cervical cancer. We characterized the vaginal mycobiota across reproductive stages and examined its associations with cervical disease, HPV status, and bacterial community state types (CSTs) in 86 Hispanic participants from Puerto Rico using ITS1 amplicon sequencing. Amplicon sequence variants were inferred with QIIME2/DADA2 and taxonomically classified using the UNITE database, with diversity and discriminant taxa analyses applied to expl

SUBMITTER: Godoy-Vitorino F 

PROVIDER: S-EPMC12871808 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature