Examining individual serotonin and norepinephrine reuptake inhibitors and fall-related hospitalizations in older adults.

ABSTRACT:

Introduction

MDD is often managed with antidepressants that may carry a fall risk. Limited data exist comparing fall risk across individual SNRIs. Therefore, this study aimed to determine the fall rates associated with SNRIs.

Methods

Data were drawn from Merative MarketScan Medicare Supplemental claims (January 1, 2015 to November 30, 2021), including adults 65 years and older prescribed an SNRI (ie, duloxetine, venlafaxine, desvenlafaxine, milnacipran, levomilnacipran). The index date was the first prescription claim. Patients were followed up to 1 month after their last prescription to identify falls, using International Classification of Diseases (ICD) 9^th Revision and ICD-10 codes. Fall-related injuries were identified using trauma codes. Descriptive statistic

SUBMITTER: White LE 

PROVIDER: S-EPMC12872345 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature