Magnesium-doped bioactive glass enhances bone regeneration by reversing replicative senescence of human dental pulp stem cells in bone defect therapy.

ABSTRACT: Human dental pulp stem cells (hDPSCs) exhibit replicative senescence during in vitro expansion, leading to a reduction in osteogenic differentiation capacity and thereby limiting their potential for bone defect regeneration. Magnesium ion (Mg²⁺), one of the most abundant divalent cations in the human body, is involved in numerous physiological processes. Mg²⁺ deficiency has been closely associated with bone fragility and various systemic aging-related diseases, underscoring its critical role in aging and bone metabolism. However, the effects of Mg²⁺ on mesenchymal stem cells (MSCs) replicative senescence remain poorly understood. In this study, we developed magnesium-doped bioactive glass (Mg-BG) powder with a graded magnesium doping ratio through th

SUBMITTER: Yan X 

PROVIDER: S-EPMC12872399 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature