CD8⁺ T cell stemness precedes post-intervention control of HIV viraemia.

ABSTRACT: Interventions to induce lasting human immunodeficiency virus (HIV) remission are needed to obviate the requirement for lifelong antiretroviral therapy. Durable post-intervention control (PIC) of viraemia has been achieved in a subset of people following administration of broadly neutralizing anti-HIV-1 antibodies (bNAb) and analytical interruption of treatment^1-4. Previous studies support a role for CD8⁺ T cells in PIC^5-9, but the precise features of CD8⁺ T cells involved remain unclear. Here we mapped and functionally profiled CD8⁺ T cell responses to autologous HIV epitopes using longitudinal samples from four analytical treatment interruption trials in bNAb recipients. PIC was associated with superior pre-intervention HIV-specific C

SUBMITTER: Kiani Z 

PROVIDER: S-EPMC12872466 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature