Sphingosine kinase 2 suppresses neutrophil responses to promote viral persistence while attenuating immune pathology.

ABSTRACT: Chronic viral infections often suppress immune cell functions, which helps restrict immune pathology but leads to viral persistence. However, the underlying mechanisms are not completely understood. We recently found that sphingosine kinase 2 (SphK2)-deficient (Sphk2 ^-/-) mice succumb to lymphocytic choriomeningitis virus (LCMV) infection due to immune pathology. In addition to heightened T cell immunity, a notable increase in neutrophil numbers was observed in LCMV-infected Sphk2 ^-/- mice. Depletion of neutrophils increased the viability of virus-infected Sphk2 ^{- / -} mice, supporting the role of SphK2-deficient neutrophils in viral immune pathogenesis. Furthermore, SphK2-deficient neutrophils expressed lowe

SUBMITTER: Vijayamahantesh V 

PROVIDER: S-EPMC12872563 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature