Indirect Comparison of Cal/BDP PAD-Cream vs Cal/BDP Foam in Patients with Plaque Psoriasis Meeting the Rule of Tens.

ABSTRACT:

Introduction

Calcipotriol and betamethasone dipropionate (Cal/BDP) PolyAphron dispersion (PAD) cream and Cal/BDP foam have demonstrated superior efficacy to Cal/BDP gel in patients with plaque psoriasis exhibiting a more severe profile defined by the Rule of Tens in different studies. However, its comparative efficacy in this subgroup of patients needs to be studied.

Methods

An indirect treatment comparison (ITC) using individual patient data for Cal/BDP PAD cream and available aggregated data for Cal/BDP foam was conducted for three outcome measures: Physician's Global Assessment (PGA) success, modified Psoriasis Area and Severity Index 75 (mPASI75), and Dermatology Life Quality Index (DLQI) satisfaction. Bucher's method was used for the ITC base case, and alternative analy

SUBMITTER: Campanati A 

PROVIDER: S-EPMC12872955 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature