DUSP1 Attenuates Renal Injury in Diabetic Nephropathy by Modulating Ferroptosis: Evidence From Animal Experiments.

ABSTRACT:

Objective

Emerging evidence suggests that ferroptosis contributes significantly to the progression of diabetic nephropathy (DN). This study aimed to explore the potential association between dual specificity phosphatase 1 (DUSP1) and ferroptosis in a streptozotocin-induced DN rat model.

Methods

We analyzed microarray datasets (GSE30122 and GSE96804) from the gene expression omnibus (GEO) database to identify ferroptosis-related differentially expressed genes (FDEGs), with particular focus on DUSP1. Experimental validation was performed using 45 specific pathogen-free Sprague-Dawley rats: 15 controls and 30 STZ-induced DN models (60 mg/kg, i.p.). After 12 weeks, successfully modeled rats (n = 28) were randomized into DN (n = 14) and DN+Ferrostatin-1 (Fer-1, a ferroptosis inhi

SUBMITTER: Liu J 

PROVIDER: S-EPMC12872968 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature