Single-cell analysis reveals cytotoxic and memory CD8⁺ T cells associated with prolonged survival in relapsed/refractory leukaemia patients after haplo+cord haematopoietic stem cell transplantation.

ABSTRACT:

Backgroud

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for haematological malignancies. Sequential transplantation of haploidentical stem cell and umbilical cord blood (haplo+cord HSCT) among recipients with relapsed/refractory (R/R) leukaemia exhibited superior survival outcomes compared with single cord HSCT. However, the underlying mechanisms remain unclear.

Methods

Here, we profiled and compared single-cell gene expression and chromatin accessibility in bone marrow from 16 patients receiving haplo+cord or single cord HSCT.

Results

We observed distinct compositions and functions of global immune landscapes, with haplo+cord HSCT exhibiting effective anti-tumour and anti-viral immunity mediated by type I interferon signallin

SUBMITTER: Li H 

PROVIDER: S-EPMC12872979 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature