Gallbladder disease and colorectal cancer: a two-sample bidirectional Mendelian randomization study.

ABSTRACT:

Objective

To assess whether a bidirectional causal relationship exists between gallbladder disease and colorectal cancer (CRC) using a two-sample, bidirectional Mendelian randomization (MR) approach based on genome-wide association study (GWAS) summary statistics.

Methods

We used European-ancestry data from the IEU OpenGWAS project within the UK Biobank. In the forward MR analysis, gallbladder disease was treated as the exposure and CRC as the outcome; in the reverse analysis, genetic liability to CRC was treated as the exposure and gallbladder disease as the outcome. The inverse variance weighted (IVW) method served as the primary analysis, supplemented by MR-Egger, weighted median, simple mode, and weighted mode methods. Instrument strength was evaluated using F statistics

SUBMITTER: Hu Q 

PROVIDER: S-EPMC12873012 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature