Genomic and transcriptomic analyses of melanoma in Japanese patients reveal candidate biomarkers for immune checkpoint inhibitor responders.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) have greatly improved advanced melanoma prognosis. However, the efficacy of ICIs in Japanese patients has been found to be lower than that in their white counterparts. We aimed to elucidate the genomic and transcriptomic features associated with response to ICIs in Japanese patients with melanoma.

Methods

A total of 129 tumor samples were collected from 78 patients with melanoma who received therapeutic regimens with or without ICI treatment. We performed exome and RNA sequencing and investigated the association between genomic and transcriptomic factors and the clinical efficacy of ICI.

Results

The number of somatic SNVs in Japanese patients with melanoma is lower than that in the TCGA white data owing to the biased dist

SUBMITTER: Kimura T 

PROVIDER: S-EPMC12873119 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature