Nutrition in early life interacts with genetic risk to influence preadult behaviour in the Raine Study.

ABSTRACT:

Background

Early life nutrition is associated with child behaviour; however, the interplay with genetic vulnerability is understudied. We hypothesised that psychiatric genetic risk interacted with early nutrition to predict behavioural problems in childhood and adolescence.

Methods

The Raine Study participants with genetic information aged 2-17 were repeatedly evaluated with the child behaviour checklist total problems score (CBCL_TOT). Breastfeeding duration was recalled at age 1, 2 and 3 follow-up, and toddler diet derived by an age-1 24-h maternal recall (EAT1, scale 0-70, SD 10, higher scores proxying healthy diet). We derived polygenic scores (PGS) impacting general psychopathology: attention-deficit hyperactivity disorder (ADHD), depression, chronic multisite

SUBMITTER: Byg LM 

PROVIDER: S-EPMC12873190 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature