The effect of Indigenous American genomic ancestry on type 2 diabetes in Mexico: an analysis of 134 548 individuals from the Mexico City Prospective Study.

ABSTRACT:

Background

The prevalence of type 2 diabetes in Mexico is among the highest in the world and a major public health problem. The aim of this study was to examine the association between the percentage of Indigenous American genomic ancestry (AMR) and the prevalence of both prediabetes and type 2 diabetes in a large study of Mexican adults.

Methods

In this cross-sectional study, we analysed data from 134 548 individuals from the Mexico City Prospective Study (MCPS), including sociodemographic, clinical, and genetic data. Type 2 diabetes was defined as a self-reported previous diagnosis, glucose-lowering medication, or glycated hemoglobin (HbA_1c) of at least 6·5%. Prediabetes was defined as HbA_1c between 5·7% and less than 6·5%. Individuals with probable t

SUBMITTER: Berumen J 

PROVIDER: S-EPMC12873227 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature