Relationships between local metabolic activity and distributed functional connectivity in major depressive disorder.

ABSTRACT: Functional neuroimaging studies have described changes in local activity or in distributed connectivity in Major Depressive Disorder (MDD). We studied the interactions between these levels of neural organization to reveal novel pathobiological signatures of MDD. We scanned 21 unmedicated MDD subjects and 21 matched non-depressed controls at rest with simultaneous ¹⁸fluorodeoxyglucose PET (FDG-PET, to measure local metabolic activity), and resting-state functional Magnetic Resonance Imaging (rsfMRI, to measure hemodynamic functional connectivity, FC). We first identified regions of interest (ROIs) with increased (hypermetabolic) or decreased (hypometabolic) glucose metabolism in depressed compared to non-depressed subjects. Next, we used these hypermetabolic and hypometabolic reg

SUBMITTER: Sun W 

PROVIDER: S-EPMC12873300 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature