Autoantibody repertoire analysis in paraneoplastic pemphigus reveals novel targets linked to mucocutaneous blistering and bronchiolitis obliterans.

ABSTRACT:

Background

Paraneoplastic autoimmunity develops as consequences of immune reactions to cancer and exhibits a wide range of clinical manifestations. The autoimmune signs are often visible before the underlying malignancy is diagnosed, and a prompt diagnosis of paraneoplasia is crucial to enable early tumor detection. We characterized the immune responses underlying the severe mucocutaneous blistering disease paraneoplastic pemphigus.

Methods

We used a two-step approach to proteome-wide autoantibody repertoire analysis and independent validation in patients with paraneoplastic pemphigus (n = 84) and non-paraneoplastic autoimmune blistering diseases (n = 103).

Results

Our findings reveal that paraneoplastic pemphigus features a broad repertoire of disease-specific autoan

SUBMITTER: Eriksson D 

PROVIDER: S-EPMC12873347 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature