Chemical and biological profiling of bioactive metabolites from the invertebrate-pathogenic fungus Gibellula scorpioides BCC 39989.

ABSTRACT: Gibellula scorpioides BCC 39989 is one of the species of spider-parasitic Gibellula (Hypocreales, Cordycipitaceae) discovered in Thailand. Investigation of the invertebrate-pathogenic fungus G. scorpioides BCC 39989 led to the isolation of eight known compounds (1-8). Their chemical structures were determined by employing extensive spectroscopic analysis. Among them, ergosterol peroxide (1) and methyl o-hydroxycinnamate (2) exhibited significant biological activities. Both compounds notably suppressed LPS-induced nitric oxide production and reduced IL-6 and TNF-α secretion in RAW264.7 macrophages. In addition, compounds 1, 2, and oleic acid (7) significantly inhibited lipid accumulation and reduced intracellular triglyceride content in 3T3-L1 adipocytes in a dose-dependent manner. Compound

SUBMITTER: Rerk-Am U 

PROVIDER: S-EPMC12873349 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature