Acute effects of selective serotonin reuptake inhibitors on cerebral glucose metabolism and blood flow.

ABSTRACT: Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed antidepressants, though their mechanisms of action beyond serotonin transporter (SERT) blockade remain unclear [1]. As previous work on BOLD signal changes remain equivocal, pharmacological multimodal neuroimaging of energy demands and blood flow (CBF) holds promise due to increased specificity of these signals. This may advance the understanding of the involved pharmacodynamic mechanisms and guide treatment strategies of highly prevalent neuropsychiatric disorders. We combine new techniques of functional positron emission tomography (fPET) with high temporal resolution (3 seconds) using [¹⁸F]FDG and simultaneously acquired pseudo-continuous arterial spin labelling (pcASL). Thus, we aimed for a highly quantita

SUBMITTER: Silberbauer LR 

PROVIDER: S-EPMC12873367 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature