Gene regulatory network transitions reveal the central transcription factors in lung adenocarcinoma progression.

ABSTRACT: Transcription factors play a central role in cancer growth, progression, and metastasis, and contribute to intratumor phenotypic plasticity that enable drug tolerance and cancer relapse. Changes in the regulatory activities of transcription factors in cancer may not always be detected from mutational signatures or differential expression of the transcription factors, as done in traditional analysis. In addition, past studies have focused on the activities of transcription factors in tumor as a whole and thus, have not fully captured the heterogeneity in gene regulation among different cell types within the tumor microenvironment. In this work, through an analysis of the transitions in regulatory network architecture and gene regulation dynamics, we identify the central transcription factor

SUBMITTER: Ray U 

PROVIDER: S-EPMC12873405 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature