Correlated Evolutionary Rates Reveal Novel Components and Cross-Compartment Connectivity in Plant Proteostasis Systems.

ABSTRACT: Plant cells rely on an interconnected network of proteins interacting at many levels (e.g. physical enzyme complexes, gene regulatory modules, and biosynthetic pathways). Pairs of proteins that interact at any of these levels have been shown to exhibit phylogenetic signatures of evolutionary rate covariation (ERC), providing a basis for detecting functional interactions among proteins. Here, we perform genome-scale ERC analyses to predict a plant protein-protein interactome network. We find a clustered set of proteins that exhibit strong signatures of ERC with the plastid caseinolytic protease (Clp) and other plastid proteostasis components, thereby forming a functional module within the network. In addition to including proteins with known or predicted functions in protein import, transcr

SUBMITTER: Gatts TC 

PROVIDER: S-EPMC12873483 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature