Causal Associations Between Gut Microbes and Heart Failure Across Multiple Etiologies: A Mendelian Randomization Study.

ABSTRACT:

Background

Gut microbiota are associated with heart failure (HF); however, the causal relationship between gut microbial communities and HF of varying etiologies remains incompletely established.

Methods

This study leveraged two-sample Mendelian randomization (MR) to investigate whether genetically determined gut microbiota features causally influence HF and its related subtypes. Instrumental variables (IVs) for gut microbiota were derived from a large-scale, genome-wide association study (GWAS) of microbial traits conducted by the MiBioGen consortium, which included 18,340 individuals. Summary statistics for HF and its subtypes were extracted from the FinnGen Release 7, encompassing 19,350 all-cause HF cases and 288,996 controls. The Wald ratio and inverse-variance weighted

SUBMITTER: Xu X 

PROVIDER: S-EPMC12873699 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature