Association of allostatic load with frailty trajectories and the mediating role of depressive symptoms.

ABSTRACT:

Background

Frailty is a dynamic, age-related condition marked by progressive loss of resilience. Its risk factors include socioeconomic status and physiological stress burden, such as allostatic load score (ALS), remain unclear. This study aims to examine the role of depression in the association between ALS and frailty trajectories.

Methods

We analyzed data from 5885 LEAD cohort participants aged 25-82 years at baseline and from 3564 participants with follow-up data. Frailty status (robust, pre-frail, frail) was defined using the Fried phenotype, and transitions between visits were assessed. ALS was calculated from 14 parameters spanning cardiovascular, metabolic, and body composition measures. Associations of ALS with frailty status at baseline and with frailty transitions

SUBMITTER: Azizzadeh M 

PROVIDER: S-EPMC12873724 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature