Glutamine supports human cytomegalovirus induced lipidome remodeling through reductive carboxylation.

ABSTRACT: Lipidome remodeling during human cytomegalovirus (HCMV) replication is a complex process that requires induction of lipogenic proteins and altered metabolite flow to support synthesis of fatty acids and lipids. HCMV infection increases the utilization of glucose and acetate to provide enough carbons to support increased demand for lipogenesis during virus replication, but other carbon contributors have not been studied. Here, we identify glutamine as a carbon source for lipogenesis during HCMV infection. Metabolic tracing with ¹³ C-labeled glutamine revealed carbons from glutamine are enriched in phospholipids and neutral lipids during infection, including phosphatidylcholine, phosphatidylethanolamine, diacylglycerol, and triacylglycerol. Additional metabolic tracing demonstrate

SUBMITTER: Mokry RL 

PROVIDER: S-EPMC12873872 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature