HIGH-FIDELITY BACKPROPAGATION THROUGH PRIMATE FOVEAL CONES.

ABSTRACT: Primate vision has exceptionally high spatial acuity and contrast sensitivity. This performance originates in specialized photoreceptors of the fovea. These cones transduce light into electrical signals in the outer segment, and convey these signals to the presynaptic terminal for transmission. Backpropagating signals are also possible, as the terminal receives gap-junctional input from neighboring cones. Such signals could influence phototransduction itself. To test this idea, we recorded electrophysiologically from both ends of single cones dissociated from the macaque fovea. We found that backpropagation was effective despite the extreme slenderness and length of these cells. Backpropagation was also effective in a passive compartmental model, indicating that amplification by voltage-ga

SUBMITTER: Wienbar SR 

PROVIDER: S-EPMC12873879 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature