A Ketogenic Diet for Treatment-Resistant Depression: A Randomized Clinical Trial.

ABSTRACT:

Importance

Preclinical evidence and case reports suggest potential therapeutic benefits of ketogenic diets (KDs) in the treatment of depression, but evidence from well-controlled randomized clinical trials (RCTs) is lacking.

Objective

To assess the efficacy of a KD compared with a control diet in adults with treatment-resistant depression (TRD).

Design, setting, and participants

This RCT was conducted between February 22 and June 15, 2024. Participants aged 18 to 65 years with TRD and a score of 15 or greater on the 9-item Patient Health Questionnaire (PHQ-9) from across the UK were included.

Intervention

Participants were randomized 1:1 to one of two 6-week dietary interventions: (1) KD of prepared foods providing less than 30 g of carbohydrates per day with w

SUBMITTER: Gao M 

PROVIDER: S-EPMC12874075 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature