Deep brain stimulation for obsessive-compulsive disorder: evolution of tractography-based targeting.

ABSTRACT:

Objective

Deep brain stimulation (DBS) in the anterior limb of the internal capsule (ALIC) for obsessive-compulsive disorder (OCD) can result in large improvements in symptoms and quality of life. However, without a consistent stimulation target within the anatomically variable ALIC region, the therapy has required long and unpredictable trial-and-error periods of parameter optimization to achieve these clinically meaningful benefits. To facilitate scalability and clinical implementation of ALIC DBS for OCD, this study aimed to demonstrate the evolution of prospective DBS targeting using patient-specific tractography.

Methods

Initially, the authors targeted a white matter map of ALIC bundles and cortical regions previously implied in DBS for OCD. They then generated a map of

SUBMITTER: Segura-Amil A 

PROVIDER: S-EPMC12874167 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature