The effects of a supervised exercise training program during pregnancy on placental cytokines, and the potential role of fetal sex and maternal weight status.

ABSTRACT:

Background

The mechanisms underlying the beneficial effects of exercise on the human placenta are poorly understood. The objective of the current study was to ascertain the influence of a supervised concurrent exercise intervention from gestational Week 17 until birth on key cytokines involved in placental development and function. Secondary aims were to explore: (a) the moderating effects of fetal sex and maternal weight status; and (b) whether gestational weight gain, lifestyle behaviors (diet, sleep patterns, and physical activity), and physical fitness (strength and cardiorespiratory fitness) mediated the effects of exercise on placental cytokines.

Methods

Seventy-six pregnant women (33 ± 4 years, mean ± SD), divided into exercise (n = 40) and control (n = 36) groups, pa

SUBMITTER: Acosta-Manzano P 

PROVIDER: S-EPMC12874604 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature