Lipid Nanoparticle Library Screen Reveals Lymphatic Endothelial Cell-Targeting Lipid Nanoparticle for Delivering Vascular Endothelial Growth Factor C mRNA after Lymphatic Injury.

ABSTRACT: Dysfunction of the lymphatic system following injury, disease, or cancer treatment can lead to lymphedema, a debilitating condition with no cure. Advances in targeted therapy have shown promise for treating diseases where conventional therapies, including broad-spectrum chemotherapy, surgical interventions, and palliative care, have often failed to achieve durable responses. As lymphatic vessels have recently emerged as a therapeutic target, nucleic acid delivery via nanoparticles to lymphatic endothelial cells (LECs) has been studied utilizing lymphatic drainage; however, there are no approaches to modulate the chemical compositions of lipid nanoparticles (LNPs) to optimize LEC specificity. To identify an LNP that effectively delivers mRNA to LECs after intradermal (ID) injection, we scre

SUBMITTER: Michalaki E 

PROVIDER: S-EPMC12874650 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature