Genomic epidemiology of antimicrobial resistance in Proteus mirabilis: core genome and plasmid-mediated drivers.

ABSTRACT: Proteus mirabilis has emerged as a clinically significant multidrug-resistant (MDR) pathogen, yet the genomic drivers and dissemination mechanisms of its antimicrobial resistance (AMR) remain poorly characterized. To address this gap, we conducted a pangenome analysis of 2,013 P. mirabilis genomes, including 1,990 publicly available strains and 23 newly sequenced clinical isolates, to delineate the species-wide AMR landscape. Our study identified 197 AMR gene subtypes spanning 12 antibiotic classes, with seven resistance determinants embedded in the core genome. Clinically critical resistance phenotypes-notably to third-generation cephalosporins and carbapenems-were strongly associated with the proliferation of β-lactamase genes (bla_TEM-1, bla_CTX-M-15, bla_NDM-1</

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12874753 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature