Genetic diversity and differentiated adaptive strategies for underrepresented populations at the crossroad of Southeast and East Asia.

ABSTRACT: The underrepresentation of populations and limited genomic diversity in Southwest China have hindered understanding of human genetic origins and the evolutionary history of health and disease. Yunnan, a biodiversity hotspot at the intersection of Southeast Asia, the Yunnan-Guizhou Plateau, and the Tibetan Plateau, is home to 25 ethnic groups, 15 of which are unique to the region. The absence of genomic data from Yunnan has constrained insights into demographic histories and biological adaptations, posing challenges to precision medicine and health equity. To fill this gap, we conducted genomic analyses of 13 ethnic groups across five language families and nine regions, integrating these data with modern and ancient Eurasian populations to create a comprehensive dataset of Yunnan population

SUBMITTER: Li X 

PROVIDER: S-EPMC12874802 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature