Whole-genome and pangenome insights into <i>Mycobacterium colombiense</i> clinical isolates from human infections.

ABSTRACT:

Background

Nontuberculous mycobacteria are opportunistic pathogens which cause infections in various tissues, with the Mycobacterium avium complex (MAC) being a major cause of pulmonary diseases. Among MAC members, Mycobacterium colombiense is a clinically significant species with recognized pathogenic potential; however, studies on its genomic structure and genetic diversity remain limited.

Methods

This study investigated the drug susceptibility profiles and performed whole-genome sequencing of 12 clinical M. colombiense isolates from the Clinical Microbiology Laboratory at Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand.

Results

Based on minimum inhibitory concentration values, moxifloxacin resistance was most prevalent (100%), f

SUBMITTER: Oungbamnet C 

PROVIDER: S-EPMC12875251 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature