Genetic variation and mRNA expression of the <i>ELOVL6</i> and <i>CRTC2</i> genes in Kalmyk cattle.

ABSTRACT: Kalmyk cattle are an important meat breed in Kazakhstan, valued for their strong physique, genetic stability, and adaptability. In this study, we investigated the mRNA expression of ELOVL fatty acid elongase 6 (ELOVL6) and CREB-regulated transcription coactivator 2 (CRTC2) across multiple tissues, and further examined their genetic variations and associations with growth and carcass traits in 200 Kalmyk cattle. Expression analysis showed that CRTC2 was most highly expressed in the heart and liver, whereas ELOVL6 was predominantly expressed in the spleen and large intestine, highlighting their tissue-specific expression patterns. In addition, we identified a polymorphic SNP (g.16511290A > G) in the 3'UTR of ELOVL6, with three genotypes (AA, AG, GG) and the

SUBMITTER: Kazhgaliyev N 

PROVIDER: S-EPMC12875334 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature