Early Microbiological and Immunological Parameters in Sandblasted, Large-Grit Acid-Etched Implant Surfaces: A Split Mouth Randomized Clinical Trial.

ABSTRACT:

Aim

To compare microbiological and immunological parameters of two sandblasted, large-grit, acid-etched implant surfaces during the first 8 weeks of healing following implant placement.

Materials and methods

A dual-center, split-mouth, randomized controlled clinical trial was conducted on patients receiving one test (modified hydrophilic surface) and one control (conventional surface) implant in different quadrants. Peri-implant crevicular fluid samples were collected at implant placement and at 1, 2, 4, and 8 weeks to assess biomarkers of inflammation (Interleukin [IL]-1β, IL-6, Tumor Necrosis Factor-α, IL-2), biomarkers of anti-inflammation (IL-4, IL-10), and biomarkers of bone metabolism (osteocalcin, osteopontin [OPN], and vascular endothelial growth factor-α [VEGF-α]).

SUBMITTER: Vilchez B 

PROVIDER: S-EPMC12875365 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature