ITIH2 in colorectal cancer metastasis: Weighted Gene Co-expression Network Analysis-guided functional validation.

ABSTRACT:

Objective

One of the main causes of death from colorectal cancer (CRC) is liver metastases; yet, little is known about the genetic factors that influence the development of these metastases. Given their proven involvement in cancer spread, we anticipated that major differentially expressed genes (DEGs) between primary and metastatic CRC could identify important molecular players in liver metastasis, with an emphasis on extracellular matrix and proteolytic processes. The purpose of this study was to use integrative bioinformatics and experimental validation to identify and functionally describe hub genes linked to CRC liver metastasis.

Methods

The differentially expressed genes (DEGs) between primary (CRC and CRC liver metastases are investigated using two microarray datasets

SUBMITTER: Zhang XF 

PROVIDER: S-EPMC12875447 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature