TGF-β1 relieves burn injury induced pain by alleviating inflammation in mouse.

ABSTRACT: Burn injuries are severe traumas characterized by tissue damage and inflammation, and pain is the common symptom of burn patients. Transforming growth factor beta 1 (TGF-β1) is a multifunctional cytokine involved in organ development, immune response, tumor biology and injury repair. This study investigates the effects of TGF-β1 on the burn injury induced pain and explore the underlying mechanisms. A mouse model of second degree burn injury was established, and spinal intrathecal injection with lentivirus was used to knockdown or overexpress TGF-β1. The assessment of mechanical allodynia and thermal hyperalgesia was adapted to evaluate the impact of TGF-β1 on the burn injury induced pain. The expressions of inflammatory factors were measured by using RT-qPCR, while immunofluorescence stain

SUBMITTER: Gao S 

PROVIDER: S-EPMC12875468 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature