SIRT7 as a context-dependent biomarker and therapeutic target: Insights from a pan-cancer study.

ABSTRACT: SIRT7 is a member of the sirtuin family and has emerged as a crucial player in cancer biology, with a multifaceted role in both tumor-promoting and tumor-suppressing activities. Despite its importance in connecting NAD+ metabolism with transcriptional regulation, a systematic analysis across multiple cancer types remains underexplored, thereby limiting our understanding of its prognostic value, mutational impact, immune associations, and therapeutic potential. Therefore, this study aims to evaluate the pan-cancer significance of SIRT7 through integrated computational approaches. We employed protein structure modeling, deep neural network-guided protein interaction analysis, cancer hallmark association, gene expression profiling, survival analysis, mutational landscape, immune infiltration

SUBMITTER: Islam KMT 

PROVIDER: S-EPMC12875470 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature