Circulating Levels of Apelin, GDF-15 and Sarcopenia: Lack of Association in the MAPT Study.

ABSTRACT:

Objectives

Apelin and GDF-15 have been proposed as biomarkers of age-related sarcopenia but evidence in human models is scarce. This study aimed to explore the associations between blood apelin and GDF-15 with sarcopenia incidence and the evolution of sarcopenia components over two years in older adults >70 years.

Design

Secondary longitudinal analysis of the Multidomain Alzheimer Preventive Trial.

Participants

Older adults (>70 years) attending primary care centers in France and Monaco.

Setting

Community.

Measurements

Serum Apelin (pg/mL) and plasma GDF-15 (pg/mL) were measured. Outcomes included sarcopenia defined by the European Working Group on Sarcopenia in Older People (EWGSOP) and its determinants (appendicular lean mass [ALM] evaluated through a

SUBMITTER: Sanchez-Sanchez JL 

PROVIDER: S-EPMC12878621 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature