Age, sex, and APOE gene-specific associations between dynapenic obesity and dementia in a large cohort.

ABSTRACT:

Objective

To investigate the associations between dynapenic obesity and the risk of dementia, and the modifying effects of age, sex, and the APOE gene, using a large population-based cohort.

Methods

279,884 participants aged 55 and above from the UK Biobank were included. The participants were classified into four categories based on body mass index and hand grip strength: healthy, obesity, dynapenia, and dynapenic obesity. The incident dementia was identified based on linked hospital records and death register data. Cox proportional hazards regression models were used to estimate the associations, followed by age-, sex-, and apolipoprotein E (APOE) gene-stratified analyses.

Results

During the median follow-up of 12.4 years, 5,170 (1.8%) participants developed dementi

SUBMITTER: Yao Z 

PROVIDER: S-EPMC12878627 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature