Cumulative lipid exposure in young adulthood and risk of midlife MASLD.

ABSTRACT:

Background & aims

The importance of maintaining optimal lipid levels across young adulthood in preventing metabolic dysfunction-associated steatotic liver disease (MASLD) is unclear. This study aimed to evaluate associations of lipid profiles through young adulthood with midlife MASLD risk and assess the mediating effect of epigenomic biomarkers.

Methods

This study included 2,577 participants from the Coronary Artery Risk Development in Young Adults study using data from baseline (Year 0 [Y0], 1985-1986) to Y25 (2010-2011). Time-weighted average (TWA) lipid exposures during young adulthood (ages 18-39 years) were estimated using up to seven measurements (Y0-Y20). Non-contrast abdominal CT scans were performed to measure steatosis at Y25 (mean age, 50 years). Blood DNA methyl

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12878633 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature