Prognostic impact of the lipid metabolism gene AGPAT4 in the tumor immune microenvironment of thyroid cancer.

ABSTRACT:

Background

Thyroid cancer (THCA) is a common malignant tumor of the endocrine system, and significant clinical challenges remain in its diagnosis and prognostic evaluation. This study aims to elucidate the role of AGPAT4 in thyroid cancer by investigating its expression, involvement in metabolic pathways, and potential as a prognostic biomarker.

Methods

We analyzed data from 512 thyroid cancer patients and 279 controls, performed differential expression analysis of AGPAT4 in thyroid cancer, analyzed the gene expression correlation of AGPAT4 in thyroid cancer, and the protein-protein interaction (PPI) network and functional enrichment analysis of AGPAT4 and its differentially expressed genes (DEGs) were constructed. The Kruskal-Wallis test and receiver operating characteristi

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12879322 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature