Ki67 in cytological specimens of pancreatic neuroendocrine tumors: A literature review and validation of automated quantification.

ABSTRACT:

Introduction

The Ki67 proliferation index is mandatory for grading, prognostication, and clinical decision-making in pancreatic neuroendocrine tumors (PanNETs). Automatic Ki67 quantification on cytology has been shown to be at least as accurate, less time-consuming, and more consistent than the current gold-standard manual determination. After a thorough literature review, we aimed to validate the Visiopharm image analysis software for automatic Ki67 quantification on diagnostic cell block material from PanNETs.

Methods

We conducted a retrospective study and assembled a cohort of 69 PanNETs from clinical routine with available endoscopic ultrasound fine needle aspiration cell block, Ki67, and synaptophysin immunostained slides. The manual Ki67 index, if available, was obtain

SUBMITTER: Narimani S 

PROVIDER: S-EPMC12879570 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature