YeiE regulates YeiH to implement sulfite stress resistance in <i>Salmonella enterica</i> serotype Typhimurium.

ABSTRACT: Sulfites are toxic, reactive sulfur species that are widespread in nature. Bacteria are exposed to sulfites during the metabolism of sulfur-containing amino acids, during respiration using sulfur-containing electron acceptors, in host environments, and as food preservatives. Despite the widespread distribution of sulfites, the mechanisms by which bacteria resist their toxic effects are poorly understood. Recent work showed that the LysR-type transcriptional regulator YeiE binds to sulfite to activate sulfite reduction gene expression. We show that YeiE is necessary for Salmonella fitness in a murine infection model. We demonstrate here that the mechanism of sulfite stress resistance is distinct from pathways of sulfur assimilation for cysteine biogenesis. YeiE is an autoregulator wh

SUBMITTER: Westerman TL 

PROVIDER: S-EPMC12880088 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature