Synthesis and biological evaluation of carabrol derivatives.

ABSTRACT: Carabrol, isolated from Carpesium macrocephalum Franch. & Sav., showed anti-inflammatory potential in LPS-induced RAW264.7 murine macrophages. We transformed the structure of carabrol and modified the carbon atoms at positions 11 and 13 to obtain a series of carabrol derivatives. The anti-inflammatory activity of 26 carabrol derivatives was synthesized and screened. Their structures were established using ¹H NMR, ¹³C NMR, and HRMS spectroscopic data. All compounds were tested against RAW264.7 cells using the Griess assay; the bioassay test suggested that most of the compounds were found to have in vitro anti-inflammatory activities with low cytotoxicity. We identified several novel carabrol derivatives, which have potent anti-inflammatory activities for

SUBMITTER: Wu H 

PROVIDER: S-EPMC12880109 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature