Gastrointestinal Mucosal Disruptions During ART-Treated SIV<i>/Plasmodium fragile</i> Co-Infection.

ABSTRACT:

Background

Human immunodeficiency virus (HIV) and Plasmodium spp., which causes malaria, are co-endemic. Previously, we showed that during antiretroviral therapy (ART)-treated simian immunodeficiency virus (SIV)/Plasmodium fragile co-infection, peripheral markers of neutrophil extracellular trap (NET) formation positively correlated with peripheral markers of disease and gastrointestinal (GI) dysfunction. However, the impact of co-infection directly in the GI mucosa is unclear. We hypothesized that ART-treated SIV/P. fragile co-infection would result in peripheral and GI immune disruption associated with exacerbated clinical manifestations of SIV and P. fragile.

Methods

Adult male rhesus macaques (RMs; n=6) were inoculated with SIVmac239, initiate

SUBMITTER: Nemphos SM 

PROVIDER: S-EPMC12880234 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature