CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in the developed world. The two forms of advanced AMD, geographic atrophy and neovascular AMD, represent different pathological processes in the macula that lead to loss of central vision. Soft drusen, characterized by deposits in the macula without visual loss, are considered to be a precursor of advanced AMD. Recently, it has been proposed that a common missense variant, Y402H, in the Complement Factor H (CFH) gene increases the risk for advanced AMD. However, its impact on soft drusen, GA, or neovascular AMD--or the relationship between them--is unclear.

Methods and findings

We genotyped 581 Icelandic patients with advanced AMD (278 neovascular AMD, 203 GA, and 100

SUBMITTER: Magnusson KP 

PROVIDER: S-EPMC1288033 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature