Dietary Fat Content Influences PanIN Progression and Pancreatic Cancer Development in Mice.

ABSTRACT: Dietary macronutrient composition has emerged as a key modulator of pancreatic tumorigenesis, yet the impact of lipid-rich diets, particularly ketogenic diets (KD) on the earliest stages of pancreatic cancer development remains unclear. To investigate how dietary lipids shape the initiation and progression of Kras-driven neoplasia, we examined the effects of low-fat diet (LFD), high-fat diet (HFD), and KD in the Ptf1a ^CreERT2 ;Kras ^G12V (Acinar ^KrasG12V ) mouse model. KD-fed mice showed the shortest survival (median 26 ± 7 days) compared with SD (87 ± 29; p = 0.02) and LFD (57 ± 27; p = 0.02), while HFD-fed mice also exhibited reduced survival relative to SD (35 ± 25; p = 0.05). KD feeding induced severe gluc

SUBMITTER: Sardarni UK 

PROVIDER: S-EPMC12880573 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature