Recapitulating the Native Tendon Environment in a Synthetic 3D Anisotropic Hydrogel as an Engineered Extracellular Matrix.

ABSTRACT: The ability of tendons to transmit forces from muscle to bone is fundamentally attributed to the hierarchical anisotropy of the tissue. After injury, disorganized fibrotic scar tissue forms during the natural healing process, resulting in inferior mechanical properties that often lead to reinjury and limited restoration of function. Therefore, intervention is necessary to facilitate regenerative healing of the tendon. Polymeric biomaterials have historically been used to guide cell behavior, showing promise for the use of topological guidance and cell-mediated matrix remodeling as mechanisms for promoting regeneration. Here, we fabricated 3D scaffolds for tenocytes using anisotropic poly(ethylene glycol)-based hydrogels that recapitulate both the biophysical and biochemical properties of t

SUBMITTER: Hebner TS 

PROVIDER: S-EPMC12880621 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature